volume 1

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Andrew Johan,Elisabet Ratri Pangestuti,Elisabet Ratri Pangestuti,Ahmad Fadilah

ABSTRACT

Background: Several researchers had found that garlic (Allium sativum) could prevent liver injury in rats intoxicated by CCl based on microscopic examinations. This study was proposed to prove that Allium sativum could decrease the level of serum glutamic-pyruvic transaminase (SGPT), glutamic-oxaloacetic transaminase (SGOT), and alkaline phosphatase (ALP) in Wistar rats treated with carbon etrachlorida (CCl).

Methods: This research was a true experimental study with the post test only control… Continue reading

Atik Madiastuti, Hermina Sukmaningtyas
ABSTRACT
Background: The study is to prove the effect of L-arginine on the macrophage phagocyte ability in mice which stre ssed by electric foot shock and Listeria monocytogenes infection. It is showed by the number of latex beads which were phagocyted by macrophage in 200 macrophage.
Methods : The study was Laboratory Experimental and using The Post Test  Only Control Group Design. The 12 male Balb/C were then divided into  2 groups and… Continue reading
Maria Belladona RS., Ratna Damma Purnawati
ABSTRACT
Background: Cyclea barbata L. Miers (cincau hijau) may increase tumor cells necrosis significantly, though no studies about the potential effect on skin cancer, besides the incidence rate of skin cancer isstill
high. This study was aimed to know the effect of C. barbata L. Miers leaves extract on the histopathology
epidermal changes of C3H that exposed with carcinogen.Methods: This was a post test only control group
design study on 20 C3H… Continue reading

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Andrew Johan*

SUMMARY

Nitric Oxide (NO) is produced in higher organisms by the oxidation of one of the terminal guanido-nitrogen atoms of L-arginine. Nitric Oxide Synthase (NOS) catalyzes the oxidation of arginine to NO and citrulline. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen (O2) are required as co-substrates.

NOS exists in three distinct isoforms: 1. constitutive neuronal NOS (NOS I or nNOS), 2. inducible NOS (NOS II or

iNOS), and 3. constitutive endothelial NOS (NOS III… Continue reading

Andrew Johan*)

SUMMARY

Nitric Oxide (NO) is produced in higher organisms by the oxidation of one of the terminal guanido-nitrogen atoms of L-arginine. Nitric Oxide Synthase (NOS) catalyzes the oxidation of arginine to NO and citrulline. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen (O2) are required as co-substrates.
NOS exists in three distinct isoforms: 1. constitutive neuronal NOS (NOS I or nNOS), 2. inducible NOS (NOS II or iNOS), and 3. constitutive endothelial NOS (NOS III or eNOS).… Continue reading