Monthly Archives: March 2016

Maria Belladona RS., Ratna Damma Purnawati
Background: Cyclea barbata L. Miers (cincau hijau) may increase tumor cells necrosis significantly, though no studies about the potential effect on skin cancer, besides the incidence rate of skin cancer isstill
high. This study was aimed to know the effect of C. barbata L. Miers leaves extract on the histopathology
epidermal changes of C3H that exposed with carcinogen.Methods: This was a post test only control group
design study on 20 C3H… Continue reading

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Andrew Johan*


Nitric Oxide (NO) is produced in higher organisms by the oxidation of one of the terminal guanido-nitrogen atoms of L-arginine. Nitric Oxide Synthase (NOS) catalyzes the oxidation of arginine to NO and citrulline. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen (O2) are required as co-substrates.

NOS exists in three distinct isoforms: 1. constitutive neuronal NOS (NOS I or nNOS), 2. inducible NOS (NOS II or

iNOS), and 3. constitutive endothelial NOS (NOS III… Continue reading