Nitric Oxide (NO) is produced in higher organisms by the oxidation of one of the terminal guanido-nitrogen atoms of L-arginine. Nitric Oxide Synthase (NOS) catalyzes the oxidation of arginine to NO and citrulline. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen (O2) are required as co-substrates.
NOS exists in three distinct isoforms: 1. constitutive neuronal NOS (NOS I or nNOS), 2. inducible NOS (NOS II or iNOS), and 3. constitutive endothelial NOS (NOS III or eNOS).… Continue reading
Maria Belladona RS.1), Ratna Damma Purnawati2)
Background: Cyclea barbata L. Miers (cincau hijau) may increase tumor cells necrosis significantly, though no studies about the potential effect on skin cancer, besides the incidence rate of skin cancer is still high. This study was aimed to know the effect of C. barbata L. Miers leaves extract on the histopathology epidermal changes of C3H that exposed with carcinogen.
Methods: This was a post test only control group design study on 20 C3H… Continue reading
Atik Madiastuti1), Hermina Sukmaningtyas2)
Background: The study is to prove the effect of L- arginine on the macrophage phagocyte ability in mice which stressed by electric foot shock and Listeria monocytogenes infection. It is showed by the number of latex beads which were phagocyted by macrophage in 200 macrophage.
Methods: The study was Laboratory Experimental and using The Post Test Only Control Group Design. The 12 male Balb/C were then divided into 2 groups and received standard lab diet… Continue reading
Sigit Adi Prasetyo1), Heny Kurniawati1), Edi Dharmana2)
Background: The stress may decrease macrophage activity that has an important role in intracellular bacteria inoculation. The aim of this study was proving that 14 days stressor could change the liver histopathology pattern of Balb/C inoculated by Listeria monocytogenes.
Methods: This was an experimental study using the post test only control group design. The samples were 12 Balb/C, divided into 2 groups; Group K (control), without any… Continue reading
Mahabara Y.P.1), A. Noviastuti2)
Background: The identification of anatomic test is one of the causes of anxiety that may be measured by Hamilton Anxiety Rating Scale (HARS). So far, there was no study in examining the anxiety scale of 2003 year’s medical students Diponegoro University who joined the Anatomic I identification test.
Methods: The cross-sectional study involved all students separated into Group I and IV of anatomic identification test. The HARS scale was used to measure… Continue reading